| 摘要 |
Synthetic peptides are extremely potent in stimulating the release of pituitary GH in mammals because they are the replicates of the native (hormone) releasing factor of the hypothalamus of the particular species, i.e. porcine, bovine, caprine and ovine. These peptides contain the following sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-R13-Leu-Gly-Gln-Leu-Se r-Ala-Arg- Lys-Leu-Leu-Gin-Asp-Ile-Met-R28-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu-Gl n-Gly-Ala- R41-Val-Arg-Leu wherein R13 is Val or Ile; R28 is Ser or Asn; and R41 is Arg or Lys. The peptide or a biologically active fragment thereof, or analogs thereof having well-known substitutions and/or additions, as well as nontoxic salts of any of the foregoing, may be administered to mammals and may be used diagnostically. The peptides are particularly useful in stimulating the release of GH so as to accelerate growth in warm-blooded non-human animals of the particular species and/or to improve aquiculture. |
