Novel organic compounds and their pharmaceutical use

摘要

There are described compounds of formula in which n is 0, 1 or 2, R<1> is a hydrocarbyl group optionally substituted with an optionally substituted phenyl group and containing from 5 to 30 carbon atoms, R<2> is optionally substituted phenyl or C1-10alkyl optionally substituted by one or more substituents selected from optionally protected hydroxyl, optionally protected carboxyl, nitrile, optionally protected tetrazolyl, -COR<6> where R<6> is C1-4alkyl, C1-4alkoxy, an optionally protected amino acid residue or -NR<7>2 where each R<7> is hydrogen or C1-4alkyl, and -NHR<8> where R<8> is hydrogen, a protecting group, an optionally protected amino acid residue, C1-4alkyl or -COR<9> where R<9> is C1-4alkyl or C1-4alkoxy, and R<3>, R<4> and R<5> are each selected from hydrogen, carboxyl, C2-5alkoxycarbonyl, C1-4alkyl, C1-4alkoxy, hydroxyl, optionally protected tetrazolyl, halo, trifluoromethyl, nitrile, nitro and -CONR<10>2 where each R<10> is hydrogen or C1-4 alkyl; and salts thereof. The compounds are leukotriene antagonists.