| 摘要 |
<p>NEW MATERIAL:A compound shown by the formula I (R1 and R2 are H, or methyl; R3 is H, OH, or methoxy; A is amino acid residue, or dipeptide residue; n is 1, or 2; amino group or functional groups in A may be protected) and its acid addition salt. EXAMPLE:2''-N-L-Lysyl-5-de-O-methyl-KA-6606 I . USE:An antibiotic, or an intermediate for preparing other antibitoics. PREPARATION:A compound shown by the formula III (e.g., 4-N-glycyl-KA-6606 II, etc.) is reacted with a compound shown by the formula HO-A-H, a compound having a protected functional group except one carboxyl group, or a reactive derivative of one carboxyl group. The protecting group is optionally eliminated, and, if necessary, the reaction product is converted into an acid addition salt.</p> |
