发明名称 |
CEPHALOSPORINS AND INTERMEDIATES;PHARMACEUTICAL COMPOSITIONS |
摘要 |
Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl or tetrazolyl group being attached through a carbon-nitrogen bond, and has the following group attached to the amino group at the 7-position: <IMAGE> wherein A represents a group of the formula, -CH2- or a group of the formula <IMAGE> in which R5 represents a hydrogen atom or an alkyl group, and the bond represents syn or anti isomer or their mixture; R3 represents a hydrogen or halogen atom; and R4 represents a hydrogen atom or an amino group which may be protected or substituted. These cephalosporins have a broad antibacterial spectrum, are stable against beta -lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally. |
申请公布号 |
NZ198350(A) |
申请公布日期 |
1985.02.28 |
申请号 |
NZ19810198350 |
申请日期 |
1981.09.14 |
申请人 |
TOYAMA CHEMICAL CO.,LTD. |
发明人 |
SADAKI, H.;NARITA, H.;IMAIZUMI, H.;KONISHI, Y.;INABA, T.;HIRAKAWA, T.;TAKI, H.;TAI, M.;WATANABE, Y.;SAIKAWA, I. |
分类号 |
C07D501/24;A61K31/545;C07D;C07D501/04;C07D501/18;C07D501/20;C07D501/38;C07D501/40;C07D501/46;C07D501/56;C07D501/57 |
主分类号 |
C07D501/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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