PROCESS FOR PRODUCING NEW AZABICYCLO-BRACKET-3.2.0-BRACKET CLOSEDHEPTANE DERIVATIVES

摘要

New bicyclic compounds of the general formula (I), wherein Y<1> and Y<2> represent a removable carbonyl protecting group, and Q is a C1-5 alkyl group or a substituted benzyl group, are prepared, e.g. in the way that leaving group X of a compound having the general formula (V), wherein X is a selectively removable esterifying group, is removed, the carboxy group of the resulting new compound of the general formula (IV> is activated and reacted then with a salt of a malonic acid hemiester, wherein the alcohol component is a C1-5 aliphatic alcohol or a substituted benzyl alcohol, the resulting new compound of the general formula (III> is reacted with a sulfonic azide in the presence of a tertiary amine, and the resulting new compound of the general formula (II> is subjected to ring closure. The compounds of the general formula (I) are pharmacologically active as beta -lactamase inhibitors or can be converted into pharmacologically active thienamycin derivatives.