NOVEL 1-PIPERAZINECARBOXAMIDE DERIVATIVES

摘要

1-piperazinecarboxamide derivatives which have formula (I), wherein R1 is a member selected from hydrogen, halogen or trifluoromethyl; wherein X is selected from formula (II), wherein R2 and R3 are the same or different and selected from hydrogen or lower alkyl; wherein Z is either oxygen or sulfur; wherein Y is -NR4R5, where R4 and R5 are the same or different and selected from hydrogen, alkyl, alkenyl, cycloalkyl, aryl, aryl-(lower alkyl), or R4 and R5 may together with the N-atom form a 5- or 6- or 7-membered saturated ring, where one of the carbon atoms may be exchanged for O, NR8 or NCOR8; wherein R6 and R7 are the same or different and selected from hydrogen or lower alkyl; wherein R8 is lower alkyl or lower alkenyl; with the provisio that when X is $(1,4)$CO then R4 is hydrogen and R5 is different from hydrogen. Pharmaceutical compositions containing said 1-piperazine-carboxamide derivatives are also described. The derivatives are useful in treating mental disorders and/or aggression in man and in treating aggression in animals and for calming animals. Different processes for preparing the derivatives are also described.