| 摘要 |
<p>The invention provides novel substituted pyrrolo¢2,1-b! and pyrido¢2,1-b!quinazolines of formula I (I) or a pharmaceutically acceptable salt thereof, wherein n is 1 or 2; each of R and R1 independently represents: a) a hydrogen or a halogen atom; b) a C1-C4 alkyl group, a - CH2OH group or a cyano group; c) a carboxy group or a group - COOR6, wherein R6 represents a C1-C6 alkyl group which may be unsubstituted or substituted by C1-C4 dialkylamino group; d) a group - wherein each of R7 and R8 independently represents a hydrogen atom or a C1-C4 alkyl group; e) amino, a C2-C6 alkanoylamino group or a formylamino group, at least one of R and R1 being different from hydrogen when n is 1; R2 represents a hydrogen atom or a C1-C4 alkyl group; each of R3, R4 and R5 independently represents a hydrogen or a halogen atom, a hydroxy group, formyloxy, a C2-C8 alkanoyloxy group, a -CF3 group, a C1-C4 alkyl group, a C1-C4 alkoxy group or a C3-C4 alkenyloxy group or adjacent groups represented by two of R3, R4 and R5, taken together, form a C1-C3 alkylenedioxy group. The compounds are active on the gastroenteric system and in particular they display anti-ulcerogenic and anti-secretory activity.</p> |
