发明名称 |
23,23-Difluoro-25-hydroxy-vitamin D3 and process for preparing same |
摘要 |
The invention provides a new derivative of vitamin D, 23,23-difluoro-25-hydroxycholecalciferol, a method for preparing said compound and various new intermediates utilized in such process. The compound is characterized by vitamin D-like activity as evidenced by its ability to increase intestinal calcium transport and serum calcium. It is further characterized by its resistance to hydroxylation at C-23, which is recognized as an essential metabolic step to the inactivation of vitamin D, and therefore should provide vitamin D-like activity of greater time duration.
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申请公布号 |
US4500460(A) |
申请公布日期 |
1985.02.19 |
申请号 |
US19830524269 |
申请日期 |
1983.08.18 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
DELUCA, HECTOR F.;TANAKA, YOKO;IKEKAWA, NOBUO;KOBAYASHI, YOSHIRO |
分类号 |
C07J1/00;C07C67/00;C07C401/00;C07J9/00;C07J17/00;C07J31/00;C07J51/00;C07J53/00;(IPC1-7):C07J9/00 |
主分类号 |
C07J1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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