摘要 |
3-(Substd.-alkoxy)-2-formylphenol derivs. of formula (I) and their salts, esters and amides were prepd. by the hydrolysis of II. In (I), Q1 is (CH2)2-CXQ1Q2 or m-C6H4X ;Q2 and Q3 are H or C1-4 alkyl; X is carboxyl or its salt; Z6 is -COOR where R is C1-4 alkyl; Q4 is (CH2)2CQ2Q3- or C6H4 gp. Compds. (I) are useful in the palliation of haemoglobinopathies, esp. sickle cell anaemia. They prevent the onset of sickling in vitro in whole homozygous human sickle-cell blood and also restore sickle cells to their normal shape.
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