| 摘要 |
PURPOSE:To obtain the titled compound having antispasmodic activity, etc., easily in high yield, without using the after-treatment such as neutralization of acid, distillation, etc., by reacting a novel starting compound with thienyl magnesium halide, and decomposing the reaction mixture with an acid. CONSTITUTION:N-Methyl-5-methoxynipecotic acid methyl methobromide of formula I is made to react with thienyl magnesium halide of formula II (X is halogen), and the obtained reaction mixture is decomposed with an acid (e.g. HCl, HBr, H2SO4, etc., preferably their diluted solution) without separating into each component to obtain the objective di-(2-thienyl).(N-methyl-5-methoxy-3-piperidylidene)methane methobromide. The compound of formula I can be prepared easily by quaternarizing N-methyl-5-methoxy-nicopetic acid methyl ester with methyl bromide. |
