摘要 |
Novel compounds of the general formula: <IMAGE> (I) and the pharmaceutically acceptable acid addition salts thereof, wherein: R1, R2, R3 and R4 are each independently hydrogen, lower alkyl, lower alkoxy, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl or lower alkyl sulfonyl; R5 is hydrogen or lower alkyl; m is 0 or 1; W is alkylene, -CH=CH-, -O-, or -N(R6)-, where R6 is lower alkyl or hydrogen; n is 0 or 1; and Q is lower alkyl, cycloalkyl or optionally substituted phenyl. These compounds combine beta -blockade and calcium entry blockade properties in the same compound and therefore are useful in therapy in the treatment of cardiovascular diseases, including myocardial infarction, hypertension, arrhythmia and variant and exercise induced angina. The compounds are also useful in immunosuppressant therapy for immune diseases, such as rheumatoid arthritis.
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