发明名称 |
NONAPRENYLAMINE DERIVATIVES |
摘要 |
<p>New nonaprenylamine derivatives having the general formula: (I) wherein n is an integer of from 0 to 2, R1 represents a hydrogen atom, a lower alkyl group or a nonaprenyl group, and R2 represents a phenyl group and the pharmaceutically acceptable acid addition salts thereof, are prepared by (a) converting nonaprenol of the formula: (II) into a corresponding halide or arylsulfonic acid ester which is thereafter reacted with a primary or secondary amino compound having the general formula: (III) wherein n, R1 and R2 have the aforesaid meanings, in the presence or absence of a base, to obtain the desired nonaprenylamine of the formula (I); or (b) oxidizing nonaprenol to a corresponding aldehyde which is then condensed with a primary amino compound having the general formula: H2N?CH2?nR2 (III') wherein n and R2 have the aforesaid meanings, to form a corresponding imino compound which in turn is reduced to obtain a nonaprenylamine of the formula (I) in which R1 is hydrogen and R2 has the aforesaid meaning. When a pharmaceutically acceptable acid addition salt is desired, the nonaprenylamine of the formula (I) thus obtained is further reacted with a pharmaceutically acceptable acid to provide the desired salt. The decaprenylamine derivatives of the formula (I) are useful for controlling virus infection of vertebrate animals.</p> |
申请公布号 |
CA1172265(A) |
申请公布日期 |
1984.08.07 |
申请号 |
CA19810376123 |
申请日期 |
1981.04.23 |
申请人 |
NISSHIN FLOUR MILLING CO., LTD. |
发明人 |
TAHARA, YOSHIYUKI;KOYAMA, HIROYASU;KOMATSU, YASUHIRO;KUBOTA, REIKO;TAKAHASHI, TOSHIHIRO |
分类号 |
A61K31/135;A61K31/13;A61P31/12;A61P35/00;C07C67/00;C07C209/00;C07C211/27;(IPC1-7):C07C87/28;C07C87/50 |
主分类号 |
A61K31/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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