摘要 |
The title compds. (I; Ar1 = aryl or 1,3-benzodioxolyl; R = H or lower alkyl; R1 = H, cyano, carboxyl, lower alkyloxycarbonyl, aminocarbonyl, mono- and di(lower alkyl) aminocarbonyl, hydroxy, lower alkyloxy, lower alkylcarbonyl, or aryl carbonyl; A = II or III; Ar2 = aryl or halogen-substituted aryl; R4 = H, lower alkyl, arylloweralkyl) were prepd. Thus, methyl 3-methyl-4-oxo-1- piperidinecarboxylate was reacted with 4-fluorobenzeneamine and mixed with sodium cyanide to give Me 4-cyano-4-((4-fluorophenyl)amino)3- methyl-1-piperidinecarboxylate, which was crystallized with trichloromethane, to give B-methyl 4-(aminocarbonyl(-4-((4- fluorophenyl)amino)-3-methyl-1-piperidine carboxylate. |