摘要 |
PURPOSE:To obtain the titled compound useful as a drug having high antiemetic action and antispasmodic action extremely in high purity, by reacting a piperazine derivative with benzhydrol. CONSTITUTION:A compound shown by the formula I (X is halogen; l and m are 1-4) or its reactive derivative at its hydroxyl group is reacted with a compound shown by the formula II(Y and Z are H, halogen, lower alkyl, lower alkoxy, trifluoromethyl, nitro, or methyleneoxy) or its reactive derivative at its hydroxyl group in a solvent such as toluene, ethylbenzene, etc. in the presence of a strong base (e.g., sodium amide, sodium hydride, metal sodium, etc.) under heating to give the desired compound shown by the formula III. Either of the compound shown by the formula I and the compound shown by the formula II is preferably used in the form of the reactive derivative, especially halide. |