发明名称 |
ANALOGIFREMGANGSMAATE VED FREMSTILLING AV NYE, TERAPEUTISK AKTIVE PEPTIDYLARGININALDEHYDDERIVATER |
摘要 |
<p>Novel peptidyl-arginine aldehyde derivatives and their salts of formula I, <IMAGE> wherein X represents a hydrogen atom, benzoyl or tert-butyloxycarbonyl group, and Y is a D-phenylalanine, beta -phenyl-D-lactic acid or D-allo-isoleucine moiety, are prepared from peptidyl-arginine aldehydes protected by an urethane type protecting group on their N- or O-terminal and/or a guanidino group, by removing the protecting group in a mixture of lower alkanols and water by means of hydrogenolysis, and eventually converting the product formed into a salt. The compounds of formula I possess valuable antithrombin activity.</p> |
申请公布号 |
NO151085(C) |
申请公布日期 |
1985.02.06 |
申请号 |
NO19790004327 |
申请日期 |
1979.12.28 |
申请人 |
RICHTER GEDEON VEGESZETI GYAR RT., |
发明人 |
BAJUSZ, SANDOR,;SZELL, ERZSEBET,;BARABAS, EVA,;BAGDY, DANIEL, |
分类号 |
C07D207/16;A61K38/55;A61P3/00;A61P7/02;A61P43/00;C07C279/24;C07D211/56;C07K5/04;C07K5/06;C07K5/065;C07K5/087;C07K14/81;(IPC1-7):C07C103/52 |
主分类号 |
C07D207/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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