摘要 |
PURPOSE:To obtain the titled polysaccharide effective as an antitumor agent, having improved water solubility under neutrality, by extracting a fruit body or mycelium of a fungus belonging to the genus Volvariella with an alkali to give a soluble fraction, oxidizing it with periodic acid, followed by reducing it. CONSTITUTION:A fruit body of a mycelium of a fungus belonging to the genus Volvariella is extracted with an alkali aqueous solution to give a soluble fraction, which is oxidized with periodic acid or its water-soluble salt. It is then reduced with sodium boron hydride, etc., to give a polysaccharide consisting of the first repeating unit shown by the formula I (D-Glu is D-glucopyranose residue; beta is bond style; figure is bond position), the second repeating unit shown by the formula II (X is D-glucopyranosyl shown by the formula III or formula VI, and the third repeating unit shown by the formula V (Y is D-glucopyranose residue shown by the formula VI or formula VII; X is linked to C with P, and O with Q is linked to gluocpyranosyl residue) wherein 4-12 of the third repeating unit exist based on 100 total numbers of three repeating units, and the sum of the second and the third repeating units is 16-33. |