| 摘要 |
<p>2,4,5-Trisubstituted thiazoles of the formula <IMAGE> (I) in which each of R1 and R2, independently of the other, represents an aryl or optionally N-oxidized heteroaryl radical each of which is unsubstituted or substituted by aliphatic hydrocarbon radicals, free, etherified or esterified hydroxy, etherified optionally S-oxidized mercapto, aliphatically substituted amino and/or trifluoromethyl, X represents thio, n represents 0, 1, or 2, and R3 represents an aliphatic hydrocarbon radical that is unsubstituted or substituted by etherified or esterified hydroxy, etherified optionally S-oxidized mercapto and/or, in a position higher than the alpha -position, by oxo and/or hydroxy and optionally contains, in addition to terminally bonded hydroxy, sulpho that is present in salt form, or represents an araliphatic hydrocarbon radical that is unsubstituted or substituted in the aryl moiety as indicated for R1 and R2, or represents a cycloaliphatic or cycloaliphatic-aliphatic hydrocarbon radical that is unsubstituted or substituted in a position higher than the alpha -position by free, etherified or esterified hydroxy, or represents a group of the formula <IMAGE> (Ia) in which m represents, 0, 1 or 2, R4 represents an aliphatic hydrocarbon radical that is unsubstituted or substituted by etherified or esterified hydroxy, optionally S-oxidized etherified mercapto or, in a position higher than the alpha -position and lower than the omega -position, by oxo and/or hydroxy and that is optionally interrupted by oxa or thia, which may also be S-oxidized, or, if n and m represent O, represents a direct bond, and R1' and R2' have one of the meanings given for R1 and R2, and pharmaceutically acceptable salts thereof are suitable for combating rheumatic disorders, preferably as active ingredients in anti-rheumatic medicaments. The invention relates to medicaments of this type and to non-chemical processes for their manufacture, and also to novel compounds of the formula I and to processes for their manufacture.</p> |
