| 摘要 |
The invention relates to 2,4,5-trifluoropyrimidine, to a process for its preparation and to a process for preparing 5-fluorouracil using the new starting compound, which is hydrolysed at a temperature of from 2 to 100 DEG C in order directly to obtain 5-fluorouracil. 2,4,5-Trifluoropyrimidine is obtained by reacting a compound of the formula <IMAGE> in which each X, independently of the others, denotes Cl or Br with a metal fluoride at a temperature of from 25 to 550 DEG C. 5-Fluorouracil is a known antitumour agent which is used to treat various types of cancer. In addition to this, 5-fluorouracil is a starting material in the preparation of certain precursors of medicaments which are metabolically converted in the body to form 5-fluorouracil, such as 1-(2-tetrahydrofuryl)-5-fluorouracil.
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