Novel compounds and compositions useful for producing analgesia.

摘要

Alkadienamide compounds, and pharmaceutically-acceptable salts thereof, of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="33" wi="44" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein X is O or S; R is straight or branched diene having from 11 to 23 carbon atoms; R<Sub>1</Sub> is H, OH, or OCH<Sub>3</Sub>; R<Sub>2</Sub> is OH or a short-chain ester; and wherein at least one of R<Sub>1</Sub> and R<Sub>2</Sub> is OH or OCH<Sub>3</Sub>. Compositions, useful for producing analgesia in humans or lower animals, comprise a safe and effective amount of: an alkadienamide, pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkadienamides are N-vanillyl- alkadienamides. Methods of treatment, comprising administering a safe and effective amount of these alkadienamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.