发明名称 |
PROCESS FOR THE PREPARATION OF OPTICALLY-ACTIVE CARBAZOLE DERIVATIVES,NEW R-AND S-CARBAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
摘要 |
A process for the preparation of S- or R-carbazole derivatives of the general formula: <IMAGE> in which R is an unsubstituted or substituted amino radical and pharmacologically acceptable salts, by either reacting R-(-)-epichlorohydrin (for the S-carbazole derivative); or reacting an S-epoxide derivative of the general formula: <IMAGE> in which R1 is the residue of a substituted sulphonic acid derivative (for the R-carbazole derivative); with 4-hydroxycarbazole and then with ammonia or a substituted amine of the general formula RH, and recovering the compound or converting it to a pharmacologically acceptable salt. The new R-(+)- and S-(-)-carbozole derivatives provided by the inventive process have unexpected beta blocking and vasodilatory properties and are useful in pharmaceutical compositions. R-(+)-carbazole derivatives are also useful for the treatment of glaucoma. |
申请公布号 |
ZA8403976(B) |
申请公布日期 |
1985.01.30 |
申请号 |
ZA19840003976 |
申请日期 |
1984.05.25 |
申请人 |
BOEHRINGER MANNHEIM GMBH. |
发明人 |
HERBERT LEINERT |
分类号 |
A61K31/40;A61K31/403;A61K31/44;A61K31/4427;A61K31/443;A61P9/08;A61P9/12;A61P25/02;C07C29/09;C07D209/56;C07D209/88;C07D303/08;C07D303/12;C07D303/14;C07D303/16;C07D317/20;C07D401/12;C07D405/12;C07D491/056 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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