| 摘要 |
A novel method of treating psoriasis which comprises administering a halomethyl derivative of alpha -amino acids of the following general structure: <IMAGE> wherein Y is FCH2-, F2CH-, F3C-, ClCH2-, Cl2CH-; Z is gamma -guanidinopropyl or RaHN(CH2)n- wherein n is the integer 3 or 4; each of Ra and Rb can be the same or different and is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched, or <IMAGE> wherein R2 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R1 is hydroxy; a straight or branched alkoxy group of from 1 to 8 carbon atoms, -NR4R5 wherein each of R4 and R5 is hydrogen or a lower alkyl group of from 1 to 4 carbon atoms, or <IMAGE> wherein R3 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; and the lactams thereof when Z is RaHN(CH2)n- and each of Ra and Rb is hydrogen; with the proviso that when Z is gamma -guanidinopropyl Y is FCH2-, F2CH- or F3C- and R1 is hydroxy; and pharmaceutically acceptable salts and individual optical isomers thereof.
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