Erythromycin D and esters thereof

摘要

Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3'',4''-di-O-acetylerythromcyin D, 3''-O-acetyl-4''-O-propionylerythromycin D and 4''-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D.