Extraction of amino an acid from aqueous mixtures thereof

摘要

Amino acids can be purpified and/or concentrated by extracting aqueous mixtures such as fermentation broths by contacting an aqueous mixture containing amino acids with an organic solution containing a water insoluble extractant selected from the group consisting of: 1. A quaternary ammonium ion having the formula: where R1, R2, R3 and R4 are aliphatic, each having from 1 to 22 carbon atoms, and together have a minimum of 25 carbon atoms, and where at least three of the four R groups are at least a C4. 2. A quaternary phosphonium ion having the formula: where R1, R2, R3 and R4 are as defined above. 3. A tertiary sulfonium ion having the formula: where R1, R2 and R3 each are aliphatic with from 1 to 22 carbon atoms, and together have a minimum of 24 carbons and where at least two of these groups are at least a C6. 4. An organic boride ion having the formula: where R1, R2, R3 and R4 are as previously defined. 5. An organic sulfonic acid selected from the group consisting of: Organic sulfonic acids having the structural formula: where R5 and R6 are aliphatic hydrocarbon groups individually with from about 6 to about 22 carbon atoms, where R5 and R6 together contain at least 18 carbon atoms, and where neither R5 nor R6 are smaller than a C6; and organic sulfonic acids having the structural formula; where R7 and R8 are aliphatic hydrocabon groups containing from about 4 to about 22 carbon atoms, where R7, R8, or the sulfonic group may be attached to positions 1-8 on the aromatic rings, and where neither R7 nor R8 is smaller than a C4, and where R7 and R8 together have at least 18 carbon atoms.