PHARMACEUTICAL FORMS, THEIR PREPARATION AND COMPOSITIONS CONTAINING THE SAME

摘要

1. Pharmaceutical form of a medicament which is represented schematically by : Carrier-Spacer arm-Drug in which : - "drug" represents an active principle containing a free amino function, selected among others from antitumoral anthracyclines, antimalarial and antileishmanial quinoleines, - "carrier" is a macromolecule of proteinic nature which is selectively endocytosed by the target cells characterized in that - "arm" is a chain of peptidic nature which is represented by the sequence X-L-Leu in which L-Leu represents a L-leucyl moiety bound through its carboxylic function to the amino function of the drug and X represents 1, 2 or 3 aminoacids which may be identical or different and are selected from L-alanine, glycine and L-leucine, and having a possibly succinylated terminal amino function, and the molar ratio drug/carrier is comprised between a and about 7.