发明名称 |
Composition comprising purified human tumour necrosis factor in conjunction with human interferon and its use. |
摘要 |
<p>A method for the production and purification of human tumor necrosis factor (hTNF) is described. This purified material, shows growth inhibitory, hemorrhagic necrosis, cytotoxicity, and cytostasis effects on a variety of human tumors and cancers. The hTNF is free of exogeneous endotoxin, bacteria, and serum factors, hTNF has a molecular weight of about 70,000 hTNF and human interferon used together have a far greater growth inhibitory or cytotoxic effect on human tumors than the sum of their separate effects. The effect is synergistic and is seen with alpha-, beta- or gamma-IFN and with natural and recombinant IFN.</p> |
申请公布号 |
EP0131789(A2) |
申请公布日期 |
1985.01.23 |
申请号 |
EP19840107242 |
申请日期 |
1984.06.23 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
OLD, LLOYD J.;CARSWELL RICHARDS, ELIZABETH;RUBIN, BERISH Y.;WILLIAMSON, BARBARA D.;PRENDERGAST, JAY S. |
分类号 |
C07K14/195;A61K35/12;A61K38/00;A61K38/16;A61K38/21;C07K14/005;C07K14/52;C07K14/525;C07K14/555;C07K14/56;C07K14/565;C07K14/57;(IPC1-7):C07K15/00;C12N5/00;C12P21/00;A61K45/02;C12N1/36;G01N33/50 |
主分类号 |
C07K14/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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