| 摘要 |
<p>Method for a solid phase synthesis of a linear combination of amino acid residues, linked via peptide bonds, starting with an amino acid residue covalently linked to a support and protected by an N-alpha-amino protecting group, comprising the following steps: (a) removing the N-alpha-amino protecting group to obtain an N-alpha-amino group, (b) adding an amino acid residue protected by an N-alpha-amino protecting group, via a peptide bond, to the N-alpha-amino group obtained in step (a) by use of a reactive protected amino acid derivative and, where necessary, a catalyst, (c) repeating steps (a) and (b) until the said liner combination has been obtained. According to the invention the said reactive protected amino acid derivative has the acyl group used to form the peptide bond activated as a pentafluorophenyl ester.</p> |
