PROCESS FOR THE PREPARATION OF 2-NITROIMIDAZOLES

摘要

2-Nitroimidazoles having filaricidal activity of the formula I wherein A is one of the groups -C(R3)=C(R1)(R2),-CHBr-CH2Br or -CH2-CCl=CH2; n is 1, 2, 3 or 4; R1 and R2 are hydrogen or C1-3-alkyl and R3 is hydrogen, C1-3-alkyl, chlorine or bromine, and processes for their preparation are described. The compounds of formula I and compounds of formula VII wherein R4 is -CH2-CH2OH, -CH2-CHOH-CH2OCH3, -CH2-CHOH-CH2OH or are useful in the treatment of filariasis is also described.