发明名称 |
Recombinant antigens from mumps virus and their use in vaccines |
摘要 |
The invention provides recombinant DNA encoding an antigen of mumps virus selected from the group comprising: (a) the full length fusion protein (F), complete with signal peptide(s) and membrane anchor domain (a) (designated herein as Fs+a+); the full length attachment protein or hemagglutinin-neuraminidase (HN); the full length nucleocapsid protein (NP); (b) the truncated fusion protein lacking the membrane anchor domain (herein designated Fs+a-); (c) a hybrid protein derived by fusion of the F, HN and/or NP proteins or portions thereof. Also within the scope of the invention are vectors comprising the DNA of the invention and a host such as a vaccinia virus, mammalian cell or bacterial cell transformed or transfected with the vector; and proteins expressed by the hosts. |
申请公布号 |
AU6964894(A) |
申请公布日期 |
1994.11.21 |
申请号 |
AU19940069648 |
申请日期 |
1994.04.26 |
申请人 |
SMITHKLINE BEECHAM BIOLOGICALS S.A. |
发明人 |
ALEX BOLLEN;SOPHIE HOUARD;ERLING CARL JACOB NORRBY;TAMAS MARK VARSANYI |
分类号 |
C12N1/21;A61K39/00;C07K14/12;C12N15/45;C12R1/19 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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