| 摘要 |
<p>The invention provides 7,8-dihydroxy-1-(sulfonylphenyl)- 2,3,4,5-tetrahydro-1H-3-benzazepines having pharmaceutical activity, in particular renal dopaminergic activity as with the preferred 6-chloro-7,8- dihydroxy-1-(p-sulfamylphenyl)-2,3,4,5- tetrahydro-1H-3-benzazepine. The invention includes O-alkanoyl derivatives thereof and pharmaceutically acceptable acid addition salts. The compounds of the invention can be prepared by reacting an appropriate 1-halosulfamylphenyl-2,3,4,5- tetrahydro-1H-3-benzazepine, protected where necessary, with ammonia or a suitable amine.</p> |
