| 摘要 |
<p>PURPOSE:To obtain the titled compound useful as an intermediate of antibacterial agent, etc., economically in an industrial scale, by reacting a specific cephem-4-carboxylic acid compound with halogenated alkyl carboxylate or carbonate, and eliminating the protecting group from the product. CONSTITUTION:The objective compound of formula III is produced by dispersing the compound of formula I [A is amino or (substituted) benzylideneimino] (e.g. 7beta-amino-3-methoxymethyl-3-cephem-4-carboxylic acid) in a solvent such as N,N- dimethylacetamide, reacting with the compound of formula II (R<1> is H or lower alkyl; R<2> is lower alkyl or lower alkoxy; X is halogen) (e.g. 1-iodoethyl isopropylcarbonate) in the presence of a base such as diisopropylamine, and removing benzylidene group when A is benzylideneimino.</p> |
