发明名称 |
Method and intermediates for producing alpha-L-aspartyl-L-phenylalanine. |
摘要 |
<p>This invention encompasses a method and intermediates for preparing a commercial sweetening agent, a-L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is converted to N-acetoacetyl-L-aspartic anhydride by reaction with acetic anhydride. N-acetoacetyl-L-aspartic anhydride is reacted with L-phenylalanine methyl ester to provide N-acetoacetyl-a-L-aspartyl-L-phenylalanine methyl ester which is converted to a-L-aspartyl-L-phenylalanine methyl ester by reaction with hydroxylamine hydrochloride.</p> |
申请公布号 |
EP0130464(A1) |
申请公布日期 |
1985.01.09 |
申请号 |
EP19840107021 |
申请日期 |
1984.06.19 |
申请人 |
G.D. SEARLE & CO. |
发明人 |
HILL, JOHN BERNARD;DRYDEN, HUGH LATIMER, JR. |
分类号 |
C07D263/42;C07K5/075;(IPC1-7):C07K5/06;C07C103/48 |
主分类号 |
C07D263/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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