GUANIDINOCYCLOHEXANECARBOXYLIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME

摘要

A compound having the formula: wherein R1 represents an indanyl, indolyl, quinolyl or chromonyl group, the group of the formula (in which R2 represents a halogen atom or a nitro group), or the group of the formula (in which R3 represents a halogen atom, or an alkyl, nitro, cyano, acetamino, aminosulfonyl, benzoyl, phenoxy or trifluoromethyl group, R4 represents a hydrogen or halogen atom, or an alkyl group, and R5 represents a hydrogen or halogen atom, or an alkyl group), or a pharmaceutically acceptable salt thereof. The compound is obtained by reacting 4-guanidinomethyl-cyclohexanecarboxylic acid or a reactive derivative thereof with a compound of the formula R1-OH wherein R1 is the same as defined above, or a reactive derivative thereof. The compound and salt exhibit strong inhibitory effects on serine proteases and also antiallergic effects.