PROSTAGLANDIN 1 IN2 XX DERIVATIVES AND PROCESS FOR THEIR PRODUCTION

摘要

The invention provides compounds of the general formula I in which R1 represents (i) a radical of the general formula OR2 in which R2 represents a hydrogen atom or an unsubstituted alkyl, cycloalkyl, aryl or heterocyclic radical, an alkyl group substituted by 1 to 3 halogen atoms, C1-4 alkoxy, C6-10 aryl, di(C1-C4) alkyl amino; tri-(C1-C4) alkyl ammonium or C6-10 aryl substituted by 1 to 3 halogen atoms, phenyl, 1 to 3, C1-4 alkyl groups, chloromethyl, fluoromethyl, trifluoromethyl, carboxyl, hydroxy or C1-4 alkoxy, or an aryl group substituted by C6-10 aryl substituted by 1-3 halogen atoms, phenyl, 1-3 C1-4 alkyl groups, chloromethyl, fluoromethyl, trifluoromethyl, carboxyl, hydroxy or C1-4 alkoxy or (ii) a radical of the general formula NHR3 in which R3 represents an acyl radical, W represents a free, etherified or esterified hydroxymethylene group or a free, etherified or esterified group, in which groups the hydroxy or etherified or esterified hydroxy group may be in the .alpha.- or .beta.- configuration, R4 represents a free, etherified or esterified hydroxy group, and R5, R6, R7, R8, R9, R10,and R11, any two or more of which may be the same or different each represents a hydrogen atom or an alkyl group having from 1 to 5 carbon atoms, R9 and R10 together may also represent a direct bond, and, when R11 represents an alkyl group, R10 may also represent a chlorine atom, cis or trans to R9 and their pharmeuctically acceptable salts, and the preparation of these compounds. The compounds have blood pressure lowering action.