摘要 |
The invention concerns compounds of the formula I <CHEM> in which R<1> is lower alkyl, cyclo(lower)alkyl, phenyl(lower)alkyl, or trifluoromethyl; R<2> is oxo, thioxo or imino; R<3> is cyano, aminocarbonyl, nitro, methylsulfonyl or aminosulfonyl; R<4>, R<5>, R<6>, R<7> and R<8> each independently is hydrogen or lower alkyl; R<9> is hydrogen, lower alkenyl, 1-piperidinyl, 1-pyrrolidinyl, 1-piperazinyl, lower alkynyl, cyclo(lower)alkyl, 2, 3 or 4-pyridinyl, 2 or 3-furanyl, 2 or 3-indolyl, 2 or 3-thienyl, 5-imidazolyl, 4-morpholinyl, phenyl, phenyl mono- or disubstituted with hydroxy or lower alkoxy, 4-thiomorpholinyl, pyrazinyl, pyridazinyl, triazinyl, pyrrolyl, pyrazolyl, thiazolyl, oxadiazolyl, thiadiazolyl, isoxazolyl, furazolyl, oxathiazolyl, quinolinyl, isoquinolinyl, pyridopyrimidinyl, benzoxazolyl, benzimidazolyl, benzthiazolyl, benzoxazinyl, benzpyronyl, isoindolyl, or indolazinyl; and m and n each independently is an integer 0 to 2; or a therapeutically acceptable addition salt thereof for use in increasing cardiac contractility in mammals. Processes for their preparation and pharmaceutical compositions containing them also disclosed. |