NOVEL SYNTHESIS PEPTIDE METHOD FOR THE PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM

摘要

The invention provides a synthetic peptide comprising at least 5 of the 11 amino acids common to the gamma chain of sub-unit A of the cholera toxin and the gamma chain of the LT toxin of Escherichia coli. The peptide is preferably constituted by a pentadecapeptide which corresponds to the following formula (I): +TR The process of synthesis is by the step by step construction of the peptide chain starting form the C terminal end of said chain, by the successive fixing of the amino acids which constitute the peptide. A novel medicament for the treatment of cholera and infectious gastro-enterites is also disclosed which comprises said synthetic peptide as an active constituent. A diagnosis agent for cholera and/or infectious gastroenterites comprises a sequence of at least the 5 amino acids of the synthetic peptide.