Method of preparing isomers of bis isoquinolinium compounds

摘要

This invention provides the neuromuscular blocking agents of formula (I): <IMAGE> I where B and C are each a group of formula (II) and are meta or para to one another: <IMAGE> II wherein D is CH2CH2 or CH=CH (preferably trans); Y is alkyl of 1-4 carbon atoms (methyl, ethyl, propyl or butyl); E and F and H or OCH3; X- is an anion, preferably pharmaceutically acceptable; and the substituted benzyl and substituted propyl groups are in a trans relationship relative to each other in the nitrogen-containing ring. Methods for preparing the compounds, pharmaceutical formulations containing the compounds, and their use are also described.