| 摘要 |
Novel fused 7-membered ring compounds represented by the following formula (I), wherein R<1> and R<2> each represents hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy or, when taken together, they represent tri- or tetra-methylene, R<3> represents hydrogen, lower alkyl or aralkyl, R<4> represents hydrogen, alkyl or optionally substituted aralkyl or cycloalkyl, and X represents S(0)n (wherein n represents an integer of 0 to 2), Y represents an optionally esterified or amidated carboxyl group, and m represents 1 or 2, and the salts thereof. These compounds have an effect of inhibiting angiotensin-converting enzyme, and are useful for diagnosis, prophylaxis or treatment of hypertension. |
