| 摘要 |
PURPOSE:To produce the titled compound useful as a synthetic raw material of pharmaceuticals, etc., in high yield, in a form separable easily from the by-products by filtration, by reacting a chloromalonic acid diester with ammonia in the presence of water under mild reaction condition using single reactor. CONSTITUTION:A chloromalonic acid diester or a chloromalonic acid diamide is made to react with ammonia in the presence of water at about 20-60 deg.C, preferably about 30-50 deg.C to obtain the objective compound. The charging amount of the ammonia is usually about 2-12mol per 1mol of the chloromalonic acid diester, etc. The amount of water used in the reaction is preferably about 0.5- 10pts.wt. per 1pt. of the chloromalonic acid compound. The chloromalonic acid diester is synthesized from malonic acid diester and chlorine, and chloromalonic acid diamide can be prepared from chloromalonic acid diester and ammonia.
|
