| 摘要 |
NEW MATERIAL:A compound shown by the formula I (Y is hydroxymethylene, or carbonyl; R is 3-15C straight-chain or branched alkyl). EXAMPLE:1-(3,4-Dihydroxyphenyl)-4-methyl-3-octanol. USE:Having strong blocking and inhibitory action on production and release of SRS-A (Slow reacting substance of anaphylaxis), useful as a drug for preventing and remedying allergic diseases such as bronchial asthma, ischemic diseases, inflammations, etc. PREPARATION:A compound shown by the formula II (R' is hydroxyl-protecting group easily removable by reduction; Y' is hydroxymethylene, etc.) is reduced, the hydroxyl-protecting group is eliminated when the hydroxyl-protecting group R' remains, to give a compound shown by the formula I . |
