| 摘要 |
Soluble gelatin capsules for controlling vulvo-vaginal infections contain a stable, dried, variable concentrate, such as a freeze-dried concentrate, of lactid acid bacteria, especially Lactobacillus acidophilus, dispersed in a pharmaceutically active fluid carrier which has a viscosity of at least 2000 cps, preferably 3000 cps, and in particular 4000 cps. The count of bacteria per capsule is at least 1x10<6>, preferably at least 1x10<7>. The water activity (aw) of the bacterial concentrate and the fluid carrier is in the range of 0.00-0.2. The fluid carrier is favourably a non-hygroscopic oil containing a viscosity-increasing agent such as starch and/or vaseline. The resulting capsules have been found to have an inhibitory activity against Candida albicans in vitro and in vivo. |
