1,3,4-Thiadiazin-2-ones

摘要

Heterocyclic compounds of the formula <IMAGE> wherein either X is -CR1R2 and Y is -O-, -S- or -NR3-, wherein R1, R2 and R3, which may be the same or different, each is hydrogen or alkyl of up to 4 carbon atoms; or X is -O-, -S- or -NH- and Y is -CR1R2- wherein R1 and R2 have the meanings stated above; wherein either R4 is hydrogen, fluoro or chloro, or alkyl, alkenyl, halogenoalkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or alkoxy each of up to 6 carbon atom, and R5, R6 and R7, which may be the same or different, each is hydrogen, fluoro, chloro, bromo or iodo, or alkyl, alkenyl, halogenoalkyl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or alkoxy each of up to 6 carbon atoms, provided that R4, R5, R6 and R7 are not all hydrogen; or R4 is bromo and R5, R6 and R7 have the meanings stated above, provided that R5, R6 and R7 are not all hydrogen; or R4 and R5 together, or R5 and R6 together, or R4 and R7 together, form the -CH=CH-CH=CH- group and the other two of R4, R5, R6 and R7 have the meanings stated above; processes for their manufacture and pharmaceutical compositions containing them. The compounds possess cardiotonic and/or antihypertensive activity.