| 摘要 |
<p>3,5-Diiodo acetyl salicylic acid is reacted with ethyl chloroformate in a mixt. of triethylamine and acetone and the mixed anhydride formed is reacted in situ with 4-amino 2-chloro alpha-(4-chloro phenyl) 5-methyl phenyl acetonitrole of formula (II) in dimethyl formamide. The solvents are removed by evaporation in vacuum, the product hydrolysed with an aq. soln. of alkali or alkaline earth carbonate or bicarbonate for 2 h. at 50-60 deg. C and finally acidified to a pH not below 5, the water removed in vacuum and the product purified by crystallisation to give the salicylamide deriv. of formula (I).</p> |
