发明名称 |
A process for the crystallization of lactitol from aqueous lactitol solution |
摘要 |
A process for the production of structurally pure lactitol crystal forms selected from the group consisting of lactitol anhydride, lactitol monohydrate, lactitol dihydrate and lactitol trihydrate. The crystallization is performed by cooling a lactitol solution from a temperature at or slightly below the highest temperature of the stability area of the respective crystalline lactitol form to a temperature at or slightly above the lowest temperature of the stability area of the crystalline lactitol form. The stability areas being defined, respectively, within the temperature limits of 100 oC and 0 oC by the intersections of the solubility lines defined by the following equations (1) to (4): anhydride: s/% = 59.6 + 0.3003 t/"C Eq.(l) monohydrate: s/% = 50.2 + 0.4346 t/"C Eq. (2) dihydrate: s/% = 39.7 + 0.6332 t/"C Eq.(3) trihydrate: s/% = 33.4 + 1.1482 t/"C Eq.(4) wherein: s is the solubility % (w/w) of each respective lactitol form calculated from the mass of lactitol and water as follows: weight of lactitol / (weight of lactitol + weight of water) x 100%; t is the temperature in oC; and by maintaining the supersaturation of said lactitol solution at a level of 1 to 8 % (w/w) above the solubility line of the respective lactitol form crystallizing in said area.
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申请公布号 |
NZ337637(A) |
申请公布日期 |
2000.10.27 |
申请号 |
NZ19980337637 |
申请日期 |
1998.03.02 |
申请人 |
XYROFIN OY |
发明人 |
NURMI, JUHA;KAIRA, MIIKKA |
分类号 |
C07H15/04;(IPC1-7):C07H15/04 |
主分类号 |
C07H15/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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