| 摘要 |
Crystalline alpha -lactose hydrate is introduced into an extruder in which there is a controlled gradual increase in the shear action and whose cylindrical casing is heated to a temperature above 100 DEG C and is extruded. Dry air is the best coolant for the hot extrudate. The process differs from known processes in that no water is added to the starting material. It is also possible to extrude other substances such as anhydrous lactose or certain substances with pharmacological activities together with the alpha -lactose hydrate. Stable tablets and capsules can be made from the anhydrous lactose prepared by the described process. <IMAGE>
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