| 摘要 |
NEW MATERIAL:The compound of formula I (R<1> and R<3> are lower alkyl; R<2> are substituted or unsubstituted benzyl, or substituted or unsubstituted phenetyl; A is 1-6C straight or branched alkylene; X and Y are halogen or NO2) or its acid addition salt. EXAMPLE:2,6-Dimethyl-4-( 2',3'-dichlorophenyl )-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester 5-[2-N-benzyl-N-methylamino)-ethyl] ester. USE:A long-acting drug having excellent pharmacological activities such as hypotensive action, vasodilating action, etc., and useful as a drug for the circulatory diseases such as stenocardia, cerebral blood flow and circulatory disorder, hypertension, ischemic cardiopathy, etc. PREPARATION:The compound of formula I can be prepared by reacting the compound of formula II with the compound of formula III and the compound of formula IV. If necessary, the product is subjected to the salt-forming reaction.
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