发明名称 Method of preparing alpha-l-aspartyl-l-phenylalanine methyl ester and its hydrochloride.
摘要 <p> alpha -L-aspartyl-L-phenylalanine methyl ester and its hydrochloride are prepared by a process which comprises dissolving alpha -L-aspartyl-L-phenylalanine beta -methyl ester in a methanol/hydrochloric acid mixture solvent which contains, when hydrochloric acid is expressed in terms of concentrated hydrochloric acid and water, 0 to 20% by volume of methanol, 8 to 55% by volume of concentrated hydrochloric acid and water (balanced) in a concentration from 0.01 mol/dl to 0.3 mol/dl; holding said solution at 0 to 60 DEG C to effect intramolecular ester exchange reaction and crystallize out the formed alpha -L-aspartyl-L-phenylalanine methyl ester as its hydrochloride; isolating said hydrochloride; and obtaining, when required, the free ester by neutralization with an alkali. The ester prepared by this process is useful as a sweetener. </p>
申请公布号 EP0127977(A2) 申请公布日期 1984.12.12
申请号 EP19840303418 申请日期 1984.05.21
申请人 AJINOMOTO CO., INC. 发明人 OZAWA, YOICHI;SHINOHARA, EMIKO;EGUCHI, CHIKAHIKO;KISHIMOTO, SHINICHI;TAKEMOTO, TADASHI
分类号 C07K5/075;(IPC1-7):07C103/52;07C102/00 主分类号 C07K5/075
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