| 摘要 |
PURPOSE:To provide a novel optical resolution agent consisting of an optically active diacetylenediol derivative and suitable for the separation of antipodes of racemic lactones, lactams, sulfoxides, esters, ketones, etc. CONSTITUTION:The objective agent consists of optically active 1,6-di(halophenyl)- 1,6-diphenyl-2,4-hexadiyn-1,6-diol of formula I (X is halogen) which is synthesized easily by the coupling reaction of the optically active 1-o-halophenylpropargyl alcohol of formula II in an organic solvent such as acetone in the presence of cuprous chloride, pyridine and oxygen. It is effective especially for the optical resolution of the lactones of formula III (Y is O or N; R' is 1-4C alkyl, NH2, OH, etc.), lactams, and cyclic ketones of formula IV (R'' is R'). The molar ratio of the charged resolution agent to the lactone, etc. is preferably 1:4-1:8.
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