| 摘要 |
Phosphonate analogues of mono-, di-, and triphosphates of antiviral nucleoside analogues. These materials are represented structurally as formula (I), wherein Z1 and Z2 are the same or different and selected from the group made up of hydrogen, the one to six carbon alkyls, phenyl and benzyl, X is H, OH, or together with Y = O, Y is H or together with X = O, n is an integer, 0, 2 or 4, R1 and R2 together complete a beta -pentofuranose sugar or R1 is H and R2 is H or -CH2OH, R3 is H or OH and B is a pirine or pyrimidine base. These materials have antiviral activity, expecially against herpes virus. Antiviral pharmaceutical preparations and their use are disclosed as well. |
