Partially retro-inverted decapeptide as a specific renin inhibitor with high resistance to enzymatic hydrolysis.

摘要

Synthesis of an analogue of the (5-14) decapeptide of equine angiotensinogen partially retro-inverted at the Phe-Phe bond, of formula:
<UnorderedLists id="ula01" listStyle="none"><ListItem>Pro-His-Pro-Phe-His-
<Chemistry id="chema01" num="0001"><Image id="ia01" he="34" wi="68" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>The retro-inverso analogue inhibits renin with high resistance to enzymatic degradation, and can be used in the treatment of renin-dependent hypertension.</ListItem></UnorderedLists>