1,N-diaryl-4,5-dihydro-1H-pyrazol-3-amines, compositions containing them and methods for their preparation.

摘要

There are described compounds of formula 1,
<Chemistry id="chema01" num="0001"><Image id="ia01" he="23" wi="55" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>in which Ar<Sub>1</Sub> and Ar<Sub>2</Sub>, which may be the same or different, each independently represent phenyl or pyridinyl, the phenyl orthe pyridinyl each optionally being substituted by one or more of halogen; hydroxy; -COOR<Sub>12</Sub>; trihalomethyl; alkoxy Cl to 6; alkyl CI to 6; -NR<Sub>1</Sub>R<Sub>2</Sub>; alkoxy CI to 6 substituted by-NR<Sub>1</Sub>R<Sub>2</Sub> or by phenyl; or alkyl CI to 6 substituted by-NR<Sub>1</Sub>R<Sub>2</Sub> or by-COOR<Sub>12</Sub>;
<UnorderedLists id="ula01" listStyle="none"><ListItem>R<Sub>1</Sub> and R<Sub>2</Sub>, which may be the same or different, each independently represent hydrogen or alkyl Cl to 6,</ListItem><ListItem>R<Sub>3</Sub> represents hydrogen, alkyl Cl to 6, alkanoyl Cl to 6, benzoyl, -COOR<Sub>6</Sub>, or -CONHR<Sub>11</Sub>,</ListItem><ListItem>R<Sub>4</Sub>, R<Sub>5</Sub>, R<Sub>6</Sub> and R<Sub>7</Sub>, which may be the same or different each independently represent hydrogen, alkyl Cl to 6 or phenyl,</ListItem><ListItem>R<Sub>8</Sub> represents alkyl Cl to 6 or aryl,</ListItem><ListItem>R<Sub>11</Sub> represents alkyl Cl to 6 or aryl,</ListItem><ListItem>R<Sub>12</Sub> represents hydrogen or alkyl Cl to 6,
and pharmaceutically acceptable derivatives thereof.</ListItem></UnorderedLists>

There are also described compositions containing the compounds and methods for their preparation.

The cbmpounds are indicated for use as pharmaceutical, eg antiinflammatory agents.